Human FGFR3 (Fibroblast Growth Factor Receptor 3), Fc and 6xHis

Manufacturer: Canvax
Availability: in stock 0 item(s)
Product Code: P21641956
SKU: PR0083
UOM: 100 μg
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High quality Recombinant Protein with proven performance in ELISA, WB, Ab Production or Protein array

Is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.

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